1986, B. A. Wallace et al., "Evaluation of Methods for the Prediction of Membrane Protein Secondary Structures," Proceedings of the National Academy of Sciences, vol. 83, no. 24, p. 9423,While some proteins clearly contain in their sequence all the information necessary to refold properly even after complete denaturation, others require the presence of membranes cotemporally with biosynthesis to ensure proper folding and insertion.
