1898, Winston Churchill, The Celebrity Chapter 8, The humor of my proposition appealed more strongly to Miss Trevor than I had looked for, and from that time forward she became her old self again; for, even after she had conquered her love for the Celebrity, the mortification of having been jilted by him remained.
(medicine) The death of part of the body.
1913, D. H. Lawrence, ,And then there's the fever and the mortification—if it took bad ways he'd quickly be gone.