(euphemistic, slang, usually pejorative) Motherfucker.
1976, Charles Durden, No Bugles, No Drums, The Viking Press (1976), ISBN 9780670514199, page 95:But this motherhumper had feet long as my legs. His boots had to be special made. He was at least six-eight,
1981, Stephen King, Cujo, Viking Press (1981), ISBN 9780670451937, page 73:I mean, if people don't chain up a dog that bites, they deserve what they get, you know? That thing . . . did you see it? I bet that motherhumper went two hundred pounds."
1993, William Shatner, Tek Secret, Ace/Putnam (1993), ISBN 9780399138928, page 142:"I'll bet you that redheaded motherhumper is behind this."