1893, Arthur Gamgee, A Textâ€Book of the Physiological Chemistry of the Animal Body, Macmillan and Co.; Volume II, Chapter XII, § 3, page 453:In a research of great interest which he performed with the aid of a patient with a præternatural anus communicating with the cæcum, Marckwald, besides shewing that the secretion of the colon possesses neither diastatic nor proteolytic power, determined that the whole large intestine is only capable of absorbing about 250 grammes of water in the course of 12 hours.