• Dysmegakaryocytopoiesis

    Alternative forms



    Full definition of dysmegakaryocytopoiesis



    1. (medicine) Dysfunctional megakaryocytopoiesis; defective maturation of bone marrow progenitor cells into megakaryocytes.
      • 1985, Grover C. Bagby, The Preleukemic Syndrome (Hemopoietic Dysplasia), CRC PressI LlcThe marrow also showed megakaryocytosis and severe dysmegakaryocytopoiesis with numerous micromegakaryocytes and micromegakaryoblasts.
      • 1989, Stuart Roath, M. Corn, Current Approaches to Bone Marrow Histopathology, CRC Press (), page 109In addition, dysmegakaryocytopoiesis, iron-laden macrophages, plasma cells and lymphoid infiltrates might be better identified in histologic sections.
      • 1994, John F. Foley, Julie M. Vose, James O. Armitage, Current Therapy in Cancer, W B Saunders Company ()Dysmegakaryocytopoiesis may include hypolobulated, hyperlobulated, or multinucleated megakaryocytes, or a reduction in their number or size.
      • 2011, Richard A. McPherson, Matthew R. Pincus, Henry's Clinical Diagnosis and Management by Laboratory Methods, Elsevier Health Sciences (), page 622Dysmegakaryocytopoiesis includes large megakaryocytes with unsegmented nuclei, micromegakaryocytes, and megakaryocytes with two or more small, unconnected nuclei. Megakaryocytes may be decreased in number.
      • 2013, Victor S. Blanchette, Vicky R. Breakey, Shoshana Revel-Vilk, SickKids Handbook of Pediatric Thrombosis and Hemostasis, Karger Medical and Scientific Publishers (), page 31Moderate thrombocytopenia due to dysmegakaryocytopoiesis, platelet dysfunction, reticulocytosis, and globin synthesis imbalance resembling beta-thalassemia have been described among patients with X-linked thrombocytopenia with beta-thalassemia.
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