2008, John Greer, John Foerster, George Rodgers, Fixos Paraskevas, Bertil Glader, Daniel Arber, Robert Means Jr, Wintrobe's Clinical Hematology: Volume One: Twelfth Edition, page 141:The binding of oxygen to the iron molecule causes the hemoglobin molecule to undergo conformational changes that affect the binding of oxygen to other heme sites.